Top definition. A pussy-ass bitch is a dude who publicly goes after another man's wife on Twitter, because he thinks that will humiliate another dude, and he thinks humiliating other people makes him look good. So then, when the woman he was disrespecting claps back at him directly, he is totally surprised, because he is a pussy-ass bitch. Donald tried to insult John's wife without even ing her, so she told him he was a pussy ass bitch , and everybody agreed with her. Jul 15 Word of the Day.